Review Aims Methods Modification Application Wound Healing Literature Years

Brain pointing of agomelatine egg lecithin free-based chitosan coated nanoemulsion.Intranasal drug delivery system has been proposed as an alternative delivery system to target agomelatine (AGO) to the brain and meliorating its bioavailability. Mucoadhesive egg lecithin nanoemulsions were optimised using D-optimal design and by investigating the effect of four independent variables: oil concentration (A), chitosan concentration (B), type of oil (C) and egg lecithin: oil (D). The answers of globule size, polydispersity index, zeta potential and drug content were measured. The optimized agomelatine mucoadhesive nanoemulsion (AGO MNE) with a desirability value of 0 was subjected to further investigations for mucoadhesion, in vitro diffusion, transmission electron microscopy and in vivo biodistribution. It demoed significantly successful distribution to the brain, the optimized AGO MNE intranasal gave a brain placing efficiency (BTE) of 278% betokening increased drug brain aiming by the nasal route compared with the intravenous route the optimized AGO MNE by intranasal had a direct transport percentage (DTP) of 64%, which signals a significant contribution of the direct nose-to-brain pathway in the brain drug delivery.

The study aimed egg lecithin mucoadhesive nanoemulsion as a successful and promising strategy to directly and efficiently deliver drug to the brain.Onion Extract capsuled on Nano Chitosan: a Promising Anticancer Agent.BACKGROUND: Onion (Allium cepa) is very rich in nutritional and pharmaceutical components, such as saponins, tannins, alkaloids, steroids, and hydroxybenzenes. Many recent researches okayed its anticancer activity against various cancer cell lines. In this paper, we attempt to improve its anticancer activity with encapsulation on nano chitosan. On the best of our knowledge, this is counted the first study that samples to increase the anticancer activity of the onion extract on nano chitosan An aqueous extract of the onion was machinated and the extract efficiency as anticancer agent was raised by encapsulating the extract on nano chitosan. The antioxidant capacity and the functional factors such as alkaloid, tannin, saponin, steroid, phenolic, and flavonoid in either the free or capsulized one were estimated the anticancer activity of the two extracts was quized against different cell descents Encapsulation of the extract on chitosan nano atoms minifyed IC(50) in different cell lineages and induced apoptosis through minifying BCL-2 level and increasing caspase-3 and caspase-9 activity Onion extract capsulised on nano chitosan can be used as protective factors from cancer, antitumor, or act synergistically with the cancer chemotherapy.

This greatly enters in amending the use of natural productions in cancer therapy instead of chemotherapy.Molecular level study of cadmium adsorption on dithiocarbamate modified chitosan.It has been readed that chemical modification of chitosan with sulfur (S) functional groups could significantly enhance its chelating capability with heavy alloys admited Cd(II) a molecular level understanding has been missing we carried out X-ray absorption fine structure (XAFS) and Fourier transformed infrared (FTIR) spectra works to bridge this knowledge gap. The terminations indicate that both Cd-O/N and Cd-S bonds exist in the complex of Cd(II) with dithiocarbamate chitosan (DTC-CTS). S functional radicals (dithiocarbamate) in DTC-CTS play the major role in complexation with Cd(II) and S content involves the adsorption mechanism. At  fucose  uses , Cd(II) is mainly adsorbed on DTC-CTS as an outer-sphere complex with two monodentate amino groupings and two water motes in tetrahedral configuration. At high S content, Cd adsorption dominantly haps by formation of an inner-sphere complex with two bidentate mononuclear S ligands in tetrahedral configuration.

This investigation provides information on the effectiveness and mechanisms of Cd(II) removal that is critical for valuing altered chitosan lotions for stabilization of Cd(II) in surface water, groundwater, soils and sediments.Efficiency of magnetic chitosan supported on graphene for removal of perchlorate ions from wastewater.